Preventing bloodstream infections


The role of the built environment and private

rooms for reducing central line-associated

bloodstream infections

Liam O’Neill1*, Sae-Hwan Park1, Frank Rosinia2¤

1 Department of Health Behavior and Health Systems, School of Public Health, University of North Texas-

Health Science Center, Fort Worth, Texas, United States, 2 Department of Anesthesiology, John Peter Smith

Hospital, Fort Worth, Texas, United States

¤ Current address: University of North Texas-Health Science Center, Fort Worth, Texas, United States *


Private hospital rooms are believed to offer some protective effect against hospital-acquired

infections, including central line-associated bloodstream infections. Yet a recent meta-anal-

ysis found the evidence-base to be lacking from a policy perspective. We sought to deter-

mine whether private rooms were associated with a lower risk of central-line infections. We

examined the discharge records of more than one million inpatients from 335 Texas hospi-

tals to determine patients that stayed in private rooms. Patients who stayed in bay rooms

had 64 percent more central line infections than patients who stayed in private rooms. Even

after adjusting for relevant covariates, patients assigned to bay rooms had a 21 percent

greater relative risk of a central line infection (p = 0.005), compared with patients assigned

to private rooms. At the hospital level, a 10% increase in private rooms was associated with

an 8.6% decrease in central line infections (p<0.001), regardless of individual patients’ room assignment. This study demonstrates and validates the use of private rooms as a structural

measure and independent predictor of hospital quality.


Each year, more than 700,000 people contract hospital-acquired infections (HAIs), making

this one of the leading causes of preventable medical errors. The most costly and dangerous

type of HAI is the central line associated bloodstream infection (CLABSI), which affects about

41,000 people annually [1]. The mortality rate due to CLABSI is 12–25 percent, which corre-

sponds to about 5,000–10,000 preventable deaths per year [2]. Moreover, CLABSIs are esti-

mated to add almost $2 billion to annual health care spending [1].

The purpose of this study is to estimate the protective effect of private hospital rooms for

lowering the risk of a CLABSI. We will explore the potential benefits of private rooms at both

the hospital-level (percentage of private rooms in a given facility) and the patient-level (assign-

ment to a private room). We shall use the following terminology throughout the article. Private rooms are single-occupancy rooms and include both isolation rooms and non-isolation rooms.

PLOS ONE | July 27, 2018 1 / 12







Citation: O’Neill L, Park S-H, Rosinia F (2018) The

role of the built environment and private rooms for

reducing central line-associated bloodstream

infections. PLoS ONE 13(7): e0201002. https://doi.


Editor: Lars-Peter Kamolz, Medical University Graz,


Received: February 23, 2018

Accepted: July 6, 2018

Published: July 27, 2018

Copyright: © 2018 O’Neill et al. This is an open access article distributed under the terms of the

Creative Commons Attribution License, which

permits unrestricted use, distribution, and

reproduction in any medium, provided the original

author and source are credited.

Data Availability Statement: The authors are

legally restricted from sharing the data underlying

this study because the data belongs to the Texas

Inpatient Public Use Data File. The price for the

2013 data is $312 – $625 per quarter, as specified

at the following website (https://www.dshs.texas.

gov/thcic/hospitals/Inpatientpudf.shtm). The

PUDFs for 2006–2011 are available for download

at no cost. Similarly, the 2013 PUDF will be made

available at no cost in the future by the TDSHS. The

authors did not have access to any “restricted” or

“redacted” inpatient data that are not contained in

the PUDF. Information on purchasing this data can



Isolation rooms typically require special ventilation systems and other features to achieve nega- tive air pressure in order to prevent the transmission of pathogens (e.g., Methicillin-resistant

Staphylococcus aureus (MRSA)). Bay rooms, also called “semi-private” rooms, may contain up to four beds that are typically separated by curtains.

Private hospital rooms have been touted as a means of reducing the risk of an HAI. How-

ever, few studies have established a definitive link between hospital design features, including

private rooms, and a reduction in HAIs [3]. In 2013, the Health Environments Research and Design (HERD) Journal had a special issue on the role of facility design in the prevention of HAIs. According to an editorial in this issue: “There is little evidence.. linking design strate-

gies.. to a reduction in infection rates, causing the experts to question the accuracy of the term

“evidence-based design”” [4]. With respect to the built environment, some researchers have

recently focused on the importance of cleaning and disinfection of patient rooms for reducing

HAIs. One study found that assignment to a hospital room that was previously occupied by a

MRSA carrier increased the relative risk of a MRSA infection by 30 percent [5]. Zuberi argued

that the outsourcing of housekeeping staff has led to unsafe conditions due to substandard

cleaning practices [6].

The structure-process-outcome (SPO) model, as first proposed by Donabedian, provides

the conceptual framework for this study [7,8]. Structural characteristics are those stable ele-

ments that are necessary, but not sufficient, to achieve excellent health outcomes. Process mea-

sures may also include organizational attributes that are fluid and dynamic, such as leadership

and communication [9].

“Private rooms” can be considered as either a structure or process measure. Process mea-

sures involve daily decisions made by physicians or nurses, such as assigning patients to beds.

Structural measures involve decisions made by hospital CEOs in consultation with architects

and other professionals. These strategic decisions pertain to the design of new hospitals or the

renovation of existing facilities.

Though the literature on private hospital rooms and infection risk is voluminous, the evi-

dence-base remains weak. Dettenkofer et al. conducted a meta-analysis of 178 articles and clas-

sified the majority of these at the lowest level of evidence (expert judgment or consensus

statements) [10]. Some studies reported a reduction in HAIs after an intervention, such as

moving to a new hospital with private rooms. Yet the results could not be generalized due to

their small sample sizes and potential confounding bias. A more recent meta-analysis of 25

studies reported similar findings and noted the lack of any randomized, controlled trials

(RCTs) [11]. The lack of multisite studies also limits the extent to which these findings can

support managerial or policy recommendations [12].

Consider five representative studies from the recent literature on private rooms and HAIs

which are summarized in Table 1 [13–17]. Only three of the five studies concluded that private

rooms reduced HAIs [14,16,17], while the other two offered more nuanced conclusions

[13,15]. In terms of sample size, the studies included at most two hospitals, no more than 49

beds, and a maximum of 19,343 patients. Moreover, none of the studies were performed in US

hospitals. By contrast, the present study includes 335 hospitals, more than 90,000 beds, and

over one million patients. By including a cross-section of hospitals, our aim is to understand

the broader context of private hospital rooms, including organizational factors, patient charac-

teristics, and environmental factors.

This paper contributes to the current literature in two ways: 1) this study aims to demon-

strate, validate, and extend the use of private rooms as a measure of the built environment in

health services research studies; 2) The study will show that private hospital rooms were associ-

ated with lower CLABSI rates, even after adjusting for patient comorbidities and other


Private rooms for reducing central line-associated bloodstream infections

PLOS ONE | July 27, 2018 2 / 12

be found at the following website: https://www.

Funding: The authors received no specific funding

for this work.

Competing interests: The authors have declared

that no competing interests exist.



By expanding the scope of analysis from one or two hospitals to hundreds of facilities, a

broader perspective is sought that may reveal the interaction of private rooms with numerous

other organizational attributes, such as hospital ownership, nurse staffing, and teaching status.

To determine the potential impact of private rooms, we also sought to better understand the

process by which patients are assigned to either a private room or a bay room.

A major obstacle to the use of private rooms as a structural measure has been the lack of

available data in secondary datasets. The state of Texas hospital inpatient database includes

“hospital room charges” at the patient level that are disaggregated by room type [18]. In con-

trast to previous studies, the present study disaggregates private rooms into “regular” private

rooms, henceforth called “single rooms,” and isolation rooms, which employ various design

features to prevent the spread of pathogens.

Our dependent variable measuring central-line infections was derived from Patient Safety

Indicator (PSI) # 7 [19]. The PSIs were originally developed by the Agency for Healthcare

Research and Quality (AHRQ) in order to identify preventable complications. Their develop-

ment, validation, and ongoing refinements have been described in detail elsewhere [20,21].

This metric has been used in numerous research studies and has been found to have good cri-

terion validity and stability over time [21,22]. However, some have argued that this metric

should not be used for public reporting or pay-for-performance due to its relatively low con-

cordance with CLABSI cases identified by chart review [23,24].

Materials and methods

The data for this study came from the 2013 Texas Inpatient Public Use Data File (TIPUDF), an

administrative data set maintained by the Texas Department of State Health Services (TDSHS)

[18]. The state database contained one principal and twenty-four secondary diagnosis codes

for each discharge and included 93% to 97% of all hospital discharges in the state. Hospital

charge data indicated the patient’s room type (private, bay (called “semi-private”), ward, and

intensive care unit (ICU).) (A more detailed explanation of how hospital room type was

defined can be found in the Appendix.) Hospital-level attributes and organizational character-

istics were obtained from the 2013 survey of the American Hospital Association (AHA). The

study included 335 short-term, acute-care hospitals including specialty hospitals, such as car-

diac, surgical, and orthopedic hospitals. Hospitals with less than 25 beds and children’s hospi-

tals were excluded.

Consistent with the inclusion criteria of PSI # 7 (Central Venous Catheter-related Blood-

stream Infections), the following patients were included in the study: medical and surgical

patients age eighteen and older, with a length of stay of two or more days. Patients with a diag-

nosis of cancer (metastatic cancer, solid tumor, and lymphoma) or HIV were excluded.

Patients with a principal ICD-9-CM diagnosis code of 999.31 (infection due to central venous

catheter) or 996.62 (Infection due to other vascular device, implant, and graft) were excluded,

as this suggested that the infection was present on admission. Patients with a CLABSI that was

Table 1. Five previous studies of private rooms and hospital-acquired infections.

Studies [13–17] Year Country Patients Beds Findings

Cepeda et al. 2005 England 866 28 HAI not reduced

Bracco et al. 2007 Canada 2,522 14 HAI reduced

Teltch et al. 2011 Canada 19,343 49 HAI reduced

Levin et al. 2011 Israel 210 12 HAI reduced

Ellison et al. 2014 Canada 1,687 35 HAI not reduced

Private rooms for reducing central line-associated bloodstream infections

PLOS ONE | July 27, 2018 3 / 12



not present-on-admission were those with a secondary diagnosis code of 999.31or 996.62 [19].

A total of 1,014,903 patients met the inclusion criteria for this study.

Comorbidities, such as congestive heart failure and diabetes, were identified using the Elix-

hauser comorbidity index, an index that includes 30 comorbidity measures [25]. Comorbidi-

ties, such as weight loss and electrolyte imbalance, have been found to increase the risk of a

CLABSI [22]. Four comorbidities, cancer (metastatic cancer, solid tumor, and lymphoma) and

HIV, were excluded, as stated above. We used the Healthcare Cost and Utilization Project’s

Clinical Classifications Software to obtain the most current definitions of the comorbidities

[26]. Another important risk factor for CLABSI is whether the patient required renal dialysis

[27]. Dialysis patients were identified using the following ICD9CM diagnosis codes: V45.1,

V45.11, and V45.12. Less than three percent (n = 14,113) of all patients assigned to private

rooms were classified as “private room medically necessary.” We used this as a proxy for

patients who were assigned to isolation rooms, since assignment to an isolation room is based

on medical exigency.

Hospitals were grouped into two categories based on their predominant room type. Group

1 hospitals (n = 218) were those with at least 50% private rooms. Group 2 hospitals (n = 117)

had more than 50% bay rooms. These groups were compared with respect to hospital charac-

teristics (number of beds, nurses-per-bed, teaching status, rural location, and ownership) and

patient characteristics (race/ethnicity, gender, number of comorbidities, length of stay, renal

dialysis (%), and intra-hospital transfers (%).) Significant differences between the groups were

identified using t-tests for ordinal variables and chi-square tests for categorical variables.

Unadjusted CLABSI rates per 100,000 patients were calculated for group 1 and group 2 hospi-

tals. CLABSI rates were also calculated by hospital room type based on a pooled sample. Wil-

son’s method was used to calculate the confidence intervals for rare events [28].

Patient-level risk-adjustment models for CLABSI were developed using logistic regression. Pre-

dictor variables included both patient characteristics (race/ethnicity, age, sex, dialysis, comorbidi-

ties (sum of)) and hospital characteristics (number of beds, nurses-per-bed, and teaching hospital).

The patient assignment model (model 1) included hospital room type (private, bay, or isolation) to

test the effect of room assignment on CLABSI risk. The hospital design model (model 2) included

the hospital’s percentage of private rooms as a predictor variable. The reason for using two models

was to separate the effects of hospital room types arising from: 1) being assigned to a private room

in general; and 2) choosing a hospital with predominantly private rooms.


A total of 1,357 CLABSI cases (134 per 100,000) were identified among the 1,014,903 patients

treated at 335 Texas hospitals during 2013. Percentage of private rooms in a given facility was

found to vary by hospital ownership. Non-profit hospitals had the highest median percentage

of private rooms (73%), followed by for-profit hospitals (45%), teaching hospitals (44%), and

public hospitals (17%). Non-Hispanic white patients were most likely to be assigned to a pri-

vate room (74%), followed by Asians (66%), Hispanics (62%), and African-Americans (57%).

Table 2 provides a comparison of Group 1 (private room) and Group 2 (bay room) hospi-

tals with respect to patient and hospital characteristics. Group 2 hospitals were more likely to

have for-profit or public ownership. Group 2 hospitals also treated more Hispanics, African-

Americans, and fewer women. They also had 30% fewer nurses-per-bed (1.10 vs. 1.56;

p< 0.001) and more patients who required renal dialysis (4.0% vs. 3.3%; p<0.001). Patients

from Group 2 hospitals had a longer length of stay (5.6 vs. 4.8; p<0.001) and more intra-hospi-

tal transfers (15.2% vs. 13.7%; p<0.001). Patients from group 1 hospitals had more comorbidi-

ties (3.28 vs. 3.24; p<0.001).

Private rooms for reducing central line-associated bloodstream infections

PLOS ONE | July 27, 2018 4 / 12



As shown in Fig 1, Group 1 hospitals had 33 percent fewer CLABSIs overall than Group 2

hospitals (115 vs. 173; P<0.001). Fifteen percent of Group 1 hospitals reported having zero

Table 2. Comparison of Group 1 (private room) hospitals and Group 2 (bay room) hospitals.

Group 1 Group 2

Variable (n = 218) (n = 117) P-value

Hospital Characteristics Beds (licensed) 230.6 263.3 0.687

Nurses-per-Bed (FTE) 1.6 1.1 <0.001

Teaching hospital (%) 8.9% 10.3% 0.791

Rural location (%) 18.2% 21.4% 0.871

Ownership (%) <0.001

Non-profit 47.1% 23.6%

Public ownership 6.7% 15.5%

For-profit 46.2% 60.9%

Patient Characteristics Number of Patients 693,966 320,937

Comorbidities, mean 3.3 3.2 <0.001

Length of stay (days) 4.8 5.6 <0.001

Dialysis rate (%) 3.3% 4.0% <0.001

Intra-hospital Transfers <0.001

Zero 86.3% 84.8%

One or more 13.7% 15.2%

Race/Ethnicity (%) <0.001

Non-hispanic White 65.0% 46.9%

Non-hispanic African-American 9.5% 11.9%

Asian 1.3% 1.7%

Hispanic 20.5% 33.8%

Other 3.7% 5.8%

Female (%) 57.5% 55.2% <0.001

Fig 1. Rate of central-line bloodstream infections at 335 Texas hospitals. Group 1 Hospitals have majority private

rooms. Group 2 Hospitals have majority bay rooms.

Private rooms for reducing central line-associated bloodstream infections

PLOS ONE | July 27, 2018 5 / 12



CLABSIs compared with only two percent of Group 2 hospitals (P<0.001). Mortality rates

among CLABSI patients were significantly higher in Group 2 compared to Group 1 (7.9% vs.

4.4%; P<0.001). Hence the risk of mortality due to CLABSI was more than twice as high in

Group 2 hospitals. Among patients assigned to private rooms, patients from Group 1 had 27

percent fewer CLABSIs than patients from Group 2 (100 vs. 136; p<0.001).

Based on the pooled results shown in Fig 2, patients who stayed in bay rooms had 64%

more CLABSIs per 100,000 than patients who stayed in private rooms (169 vs. 103; p<0.001).

There was no significant difference in CLABSI rates between patients assigned to bay rooms

compared to isolation rooms (169 vs. 170; p>0.05.)

As shown in Tables 3 and 4, a higher risk of CLABSI was associated with being African-

American, Hispanic, male, having more comorbidities, and requiring kidney dialysis. CLABSI

risk was also higher for teaching hospitals and those with fewer nurses-per-bed. Lower CLABSI

risk was associated with being female, being non-Hispanic white, increased age, fewer comor-

bidities, and more nurses-per-bed.

After adjusting for relevant covariates, model 1 results show that patients who were

assigned to a bay room were 1.21 times (CI: 1.06, 1.38; p = 0.005) more likely to develop a

CLABSI, compared with patients assigned to a private room. Whereas isolation rooms may

offer some protective benefit, the odds ratio of 0.648 was inconclusive, as it was not significant

at the one-percent level (p = 0.044).

As shown in Table 4, a higher percentage of private rooms in a given hospital was associated

with a lower risk of CLABSI for all patients, regardless of room assignment. Hence patients

could potentially reduce their CLABSI risk simply by choosing a hospital with a high percent-

age of private rooms. Based on the odds ratio of 0.991 for private room (%), a hospital could

reduce its CLABSI infections by about 8.6% for every 10% increase in private rooms. These

results indicate that hospitals with mostly private rooms may have some protective effect or

“positive externality” that benefits all hospital patients, including those assigned to bay rooms.


We found a positive association between the percentage of bay rooms in a given hospital and

CLABSI rates, even after adjusting for patient risk factors and other variables. Among patients

who stayed in Group 2 hospitals, those who were assigned to private rooms had a 24% relative

risk reduction for CLABSI compared to those who stayed in bay rooms. These findings are

consistent with case study reports on the best practices for reducing CLABSIs, which include

Fig 2. CLABSI Rates based on type of hospital room where patient stayed.

Private rooms for reducing central line-associated bloodstream infections

PLOS ONE | July 27, 2018 6 / 12



moving to an all-private room design [29]. Though often yielding important insights, previous

studies were constrained by small sample sizes and potential confounders. By contrast, the

present study included over one million patients and 335 acute-care hospitals from a single


Table 3. Impact of room assignment and other variables on CLABSI risk.

Adjusted Odds Ratio P-value

Variable (95% CI)

Patient Factors Room Type Assigned

Baseline: Private Room — — Bay Room 1.212 (1.060–1.385) 0.005

Isolation Room 0.648 (0.425–0.989) 0.044

Age 0.976 (0.972–0.979) <0.001

Female 0.578 (0.508–0.658) <0.001


Baseline: White, non-Hispanic — — African-American, non-Hispanic 6.348 (5.345–7.538) <0.001

Asian 0.669 (0.249–1.799) 0.426

Hispanic 1.397 (1.163–1.679) <0.001

Other/Unknown 7.136 (5.794–8.788) <0.001

Comorbidity 1.386 (1.347–1.426) <0.001

Dialysis 2.868 (2.422–3.396) <0.001

Hospital Characteristics Beds (in 00s) 0.955 (0.935–0.976) <0.001

Nurses-per-Bed 0.493 (0.431–0.565) <0.001

Teaching hospital 2.021 (1.710–2.388) <0.001

Table 4. Impact of hospital private room (%) on CLABSI risk.

Adjusted Odds Ratio P-value

Variable (95% CI)

Patient Factors Age 0.976 (0.972–0.980) <0.001

Female 0.589 (0.518–0.670) <0.001


Baseline: White, non-Hispanic — African-American, non-Hispanic 5.934 (5.004–7.038) <0.001

Asian 0.631 (0.235–1.695) 0.361

Hispanic 1.378 (1.148–1.655) 0.001

Other/Unknown 6.417 (5.212–7.902) <0.001

Comorbidity 1.391 (1.352–1.431) <0.001

Dialysis 2.894 (2.444–3.427) <0.001

Hospital Characteristics Private Rooms (%) 0.991 (0.989–0.993) <0.001

Beds (in 00s) 0.953 (0.933–0.974) <0.001

Nurses-per-Bed 0.49 (0.428–0.561) <0.001

Teaching hospital 2.005 (1.703–2.360) <0.001

Private rooms for reducing central line-associated bloodstream infections

PLOS ONE | July 27, 2018 7 / 12



This study also found that hospitals with mostly private rooms, that is, Group 1 hospitals,

also had a shorter length of stay, fewer intra-hospital transfers, and higher nurse staffing levels

than Group 2 hospitals. Each of these has also been associated with fewer HAIs and lower

CLABSI rates. They also suggest the various pathways by which private rooms can facilitate

better outcomes. Private rooms have also been found to foster improved communication and

coordination among clinical staff [30].

Nurse staffing was found to play an important role in reducing CLABSI rates, and this find-

ing is consistent with four previous studies [31–34]. Group 1 hospitals had 42% more nurses

per bed than Group 2 hospitals, which partly reflects the added nurse staffing requirements of

the private-room design [31]. “Nurses-per-bed” was also a significant predictor of CLABSI

risk. Based on the results of the logistic model in Tables 3 and 4, a 10% increase in nurses per

bed was associated with a 6.7% decrease in a hospital’s CLABSI rate.

Of all the patients assigned to some type of private room, less than three percent of patients

(n = 14,113) were assigned to a private room due to “medical necessity.” These patients had

more comorbidities (3.6 vs. 3.0; p<0.001) and were twice as likely to require hemodialysis (6%

vs. 3%; p<0.001) compared to patients assigned to regular private rooms. That is, these

patients had multiple risk factors for CLABSI. After adjusting for these factors, CLABSI rates

for patients in isolation rooms were not measurably different than those assigned to (non-iso-

lation) private rooms. Hence there was no clear evidence that isolation rooms provided any

additional protective effect, beyond that of a regular private room. This is consistent with two

previous studies [13,35]. Cepeda et al. argued that any potential benefit from transferring a patient to an isolation room must be weighed against the risk from the transfer itself [13].

Another study found that patients in isolation had less frequent contact with nurses [35].

We also found significant differences in the likelihood of being assigned to a private room

by race/ethnicity. Compared with non-Hispanic whites, African-Americans were 1.63 times

more likely and Hispanics were 1.44 times more likely to stay in a bay room. Most of these dif-

ferences appear to be driven by the hospital’s geographic location.

Our study has several limitations. Because our data come from a single state, caution is war-

ranted in generalizing our findings to other hospital populations. Texas has a diverse popula-

tion, geographic diversity, population growth, and numerous hospitals. It is also one of

thirteen states that does not have certificate-of-need (CON) laws that may limit the building of

new hospitals [36]. Texas is also one of 27 states that mandate public reporting of CLABSI

rates [37]. In spite of this limitation, we believe that our study represents an advance over pre-

vious small-sample studies and provides a basis for further research in this area.

Finally, we acknowledge the limits of our measure of CLABSIs, which is one of the patient

safety indicators. While the PSIs have been used in health services research studies since 2003,

their use remains controversial, especially as it relates to pay-for-performance and public

reporting [23,38]. However, each approach for identifying patient safety events is subject to

criticism, regardless of whether such measures are derived from discharge abstract databases

or from patient chart abstracts [12]. Although much progress has been made in recent years,

there remains a need for better documentation of CLABSIs and other HAIs, as well as stan-

dardized data collection mechanisms [37]. According to Rivard, Rosen, and Carroll, PSIs are

best used as higher-level measures of patient safety rather than as definitive indicators of pre-

ventable events [39].

The primary advantage of including data on more than one million patients is that it can

yield insights into the “epidemiology” of private hospital rooms, as well as the process by which

patients are “sorted” into bay rooms and private rooms. Moreover, these results show the inter-

dependence of private rooms with other important organizational factors that constitute the

broader environment in which care is delivered.

Private rooms for reducing central line-associated bloodstream infections

PLOS ONE | July 27, 2018 8 / 12



Since 2006, private rooms have become the predominant room type for new hospital con-

struction within the US, and the prevalence of bay rooms has declined over time [30]. The rea-

sons for this are complex and well-documented elsewhere [40,41]. According to our findings,

the bay room is still the most prevalent room type for public hospitals and within certain hos-

pital markets, such as those in the southern and western regions of the state.

The rise of the private hospital room has coincided with many other changes in the built

environment, such as decentralized nursing stations, acuity-adaptable rooms [42], use of anti-

microbial surfaces, and improved air filtration [4,30]. Many experts believe that the cumulative

impact of these design changes that are associated with modern facilities has created a safer

hospital and a better healing environment [4,30,41]. These same experts also concede that

there are few well-designed studies linking changes in the physical environment to better clini-

cal outcomes and a reduction in HAIs [4,30].

According to a recent CDC report, the incidence of HAIs has decreased significantly since

2008, and CLABSI rates have fallen by about 50 percent [43]. While the main causes for this

have been well-documented elsewhere [44], it is likely that changes in the built environment

and improvements in hospital design have also played a significant role.

Due to data limitations, it was not possible to separate the protective effect of private rooms

from that of other hospital design trends mentioned earlier. Thus, private rooms may also be a

proxy variable for a newer hospital with a more modern design. Even within a given hospital,

design features and physical layout may vary by floor or unit, especially for older facilities that

have been renovated or expanded. To further validate our methodology and findings, we col-

laborated with a nearby safety-net hospital and presented our recommendations on the bene-

fits of the all private-room design for a planned hospital expansion project. We also examined

whether private rooms and bay rooms within this facility differed with respect to other design

features such as sink placement, acuity-adaptable beds, and air filtration systems.

Finally, this study focused on only one potential benefit of private rooms, that is, their pro-

tective effect for reducing the number of CLABSIs and other HAIs. Yet there are numerous

other potential benefits of private rooms that warrant further study. These include: improved

patient privacy, reduced medical errors, improved nurse satisfaction, reduced noise, improved

sleep, and reduced length of stay [31]. Future research should extend this analysis to include a

broader scope of process and outcome measures, such as measures of patient and employee


Supporting information

S1 Appendix. Estimating the percentage of private rooms for each hospital.


Author Contributions

Conceptualization: Liam O’Neill.

Data curation: Frank Rosinia.

Formal analysis: Sae-Hwan Park.

Investigation: Liam O’Neill, Sae-Hwan Park.

Methodology: Liam O’Neill, Sae-Hwan Park.

Validation: Sae-Hwan Park, Frank Rosinia.

Writing – original draft: Liam O’Neill.

Private rooms for reducing central line-associated bloodstream infections

PLOS ONE | July 27, 2018 9 / 12



Writing – review & editing: Liam O’Neill, Sae-Hwan Park, Frank Rosinia.

References 1. Zimlichman E, Henderson D, Tamir O, Franz C, Song P, Yamin CK, et al. Health Care–Associated

Infections: A Meta-analysis of Costs and Financial Impact on the US Health Care System. JAMA Intern

Med. 2013 Dec 9; 173(22):2039–46. PMID:


2. Liang SY, Marschall J. Commentary: Update on Emerging Infections: News From the Centers for Dis-

ease Control and Prevention. Annals of Emergency Medicine. 2011; 58(5):450–451.

3. Hall KK, Kamerow DB. Understanding the role of facility design in the acquisition and prevention of

healthcare-associated infections. HERD: Health Environments Research & Design Journal. 2013; 7


4. Lenfestey NF, Denham ME, Hall KK, Kamerow DB. Expert opinions on the role of facility design in the

acquisition and prevention of healthcare-associated infections. HERD: Health Environments Research

& Design Journal. 2013; 7(1_suppl):31–45.

5. Datta R, Platt R, Yokoe DS, Huang SS. Environmental Cleaning Intervention and Risk of Acquiring Mul-

tidrug-Resistant Organisms From Prior Room Occupants. Arch Intern Med. 2011 Mar 28; 171(6):491–

4. PMID: 21444840

6. Zuberi D. Cleaning Up: How Hospital Outsourcing Is Hurting Workers and Endangering Patients. 1 edi-

tion. Ithaca: ILR Press; 2013.

7. Donabedian A. Evaluating the quality of medical care. The Milbank memorial fund quarterly. 1966; 44


8. Donabedian A. The definition of quality: a conceptual exploration. Explorations in quality assessment

and monitoring. 1980; 1:3–31.

9. Hearld LR, Alexander JA, Fraser I, Jiang HJ. How do hospital organizational structure and processes

affect quality of care? A critical review of research methods. Medical Care Research and Review. 2008;

65(3):259–299. PMID: 18089769

10. Dettenkofer M, Seegers S, Antes G, Motschall E, Schumacher M, Daschner FD. Does the architecture

of hospital facilities influence nosocomial infection rates? A systematic review. Infect Control Hosp Epi-

demiol. 2004 Jan; 25(1):21–5. PMID: 14756214

11. Glind I van de, Roode S de, Goossensen A. Do patients in hospitals benefit from single rooms? A litera-

ture review. Health Policy. 2007 Dec 1; 84(2):153–61.

12. Weiner BJ, Alexander JA, Baker LC, Shortell SM, Becker M. Quality improvement implementation and

hospital performance on patient safety indicators. Medical Care Research and Review. 2006; 63(1):29–

57. PMID: 16686072

13. Cepeda JA, Whitehouse T, Cooper B, Hails J, Jones K, Kwaku F, et al. Isolation of patients in single

rooms or cohorts to reduce spread of MRSA in intensive-care units: prospective two centre study. The

Lancet. 2005 Jan 22; 365(9456):295–304.

14. Bracco D, Dubois M-J, Bouali R, Eggimann P. Single rooms may help to prevent nosocomial blood-

stream infection and cross-transmission of methicillin-resistant Staphylococcus aureus in intensive care

units. Intensive Care Med. 2007 May 1; 33(5):836–40.

PMID: 17347828

15. Ellison J, Southern D, Holton D, Henderson E, Wallace J, Faris P, et al. Hospital ward design and pre-

vention of hospital-acquired infections: A prospective clinical trial. Canadian Journal of Infectious Dis-

eases and Medical Microbiology. 2014; 25(5):265–70. PMID: 25371689

16. Levin PD, Golovanevski M, Moses AE, Sprung CL, Benenson S. Improved ICU design reduces acquisi-

tion of antibiotic-resistant bacteria: a quasi-experimental observational study. Crit Care. 2011; 15(5):

R211. PMID: 21914222

17. Teltsch DY, Hanley J, Loo V, Goldberg P, Gursahaney A, Buckeridge DL. Infection Acquisition Follow-

ing Intensive Care Unit Room Privatization. Arch Intern Med. 2011 Jan 10; 171(1):32–8.

10.1001/archinternmed.2010.469 PMID: 21220658

18. Texas Department of State Health Services. Texas Inpatient Public Use Data File [Internet]. 2017 [cited

2017 Oct 12]. Available from:

19. PSI 07 Central Venous Catheter-Related Blood Stream Infection [Internet]. 2012 [cited 2017 Oct 12].

Available from:


20. Romano PS, Geppert JJ, Davies S, Miller MR, Elixhauser A, McDonald KM. A national profile of patient

safety in US hospitals. Health Affairs. 2003; 22(2):154–166. PMID: 12674418

Private rooms for reducing central line-associated bloodstream infections

PLOS ONE | July 27, 2018 10 / 12



21. Rosen AK, Itani KM, Cevasco M, Kaafarani HM, Hanchate A, Shin M, et al. Validating the patient safety

indicators in the Veterans Health Administration: do they accurately identify true safety events? Medical

care. 2012; 50(1):74–85. PMID: 21993057

22. Studnicki J, Ekezue BF, Tsulukidze M, Honoré P, Moonesinghe R, Fisher J. Disparity in Race-Specific

Comorbidities Associated With Central Venous Catheter–Related Bloodstream Infection (AHRQ-PSI7).

American Journal of Medical Quality. 2013; 28(6):525–532.

1062860613480826 PMID: 23526359

23. Winters BD, Bharmal A, Wilson RF, Zhang A, Engineer L, Defoe D, et al. Validity of the agency for

health care research and quality patient safety indicators and the centers for medicare and medicaid

hospital-acquired conditions: a systematic review and meta-analysis. Medical care. 2016; 54(12):1105–

1111. PMID: 27116111

24. Van Mourik MS, van Duijn PJ, Moons KG, Bonten MJ, Lee GM. Accuracy of administrative data for sur-

veillance of healthcare-associated infections: a systematic review. BMJ open. 2015; 5(8):e008424. PMID: 26316651

25. Elixhauser A, Steiner C, Harris DR, Coffey RM. Comorbidity measures for use with administrative data.

Medical care. 1998; 36(1):8–27. PMID: 9431328

26. HCUP CCS. Clinical Classifications Software (CCS) for ICD-9-CM [Internet]. 2017. Available from:

27. Gallagher B, Cen L, Hannan EL. Readmissions for selected infections due to medical care: expanding

the definition of a patient safety indicator. 2005; Available from:


28. Brown LD, Cai TT, DasGupta A. Interval estimation for a binomial proportion. Statistical science.


29. Edwards JN, Silow-Carroll S. Eliminating Central Line Infections and Spreading Success at High-Per-

forming Hospitals [Internet]. 2011 [cited 2017 Oct 12]. Available from: http://www.commonwealthfund.


30. Bartley J, Streifel AJ. Design of the environment of care for safety of patients and personnel: does form

follow function or vice versa in the intensive care unit? Critical care medicine. 2010; 38:S388–S398. PMID: 20647797

31. Chaudhury H, Mahmood A, Valente M. Advantages and Disadvantages of Single-Versus Multiple-

Occupancy Rooms in Acute Care Environments: A Review and Analysis of the Literature. Environment

and Behavior. 2005 Nov; 37(6):760–86.

32. Fridkin SK, Pear SM, Williamson TH, Galgiani JN, Jarvis WR. The role of understaffing in central

venous catheter-associated bloodstream infection. Infection Control & Hospital Epidemiology. 1996; 17


33. Stone PW, Mooney-Kane C, Larson EL, Horan T, Glance LG, Zwanziger J, et al. Nurse working condi-

tions and patient safety outcomes. Medical care. 2007; 45(6):571–578.

0b013e3180383667 PMID: 17515785

34. Chaudhury H, Mahmood A, Valente M. Nurses’ perception of single-occupancy versus multioccupancy

rooms in acute care environments: an exploratory comparative assessment. Applied Nursing Research.

2006; 19(3):118–125. PMID: 16877190

35. Evans HL, Shaffer MM, Hughes MG, Smith RL, Chong TW, Raymond DP, et al. Contact isolation in sur-

gical patients: a barrier to care? Surgery. 2003; 134(2):180–188.

PMID: 12947316

36. National Conference of State Legislatures. CON-Certificate of Need State Laws [Internet]. 2017 [cited

2017 Oct 12]. Available from:


37. Marsteller JA, Hsu Y-J, Weeks K. Evaluating the impact of mandatory public reporting on participation

and performance in a program to reduce central line–associated bloodstream infections: Evidence from

a national patient safety collaborative. American journal of infection control. 2014; 42(10):S209–S215.

38. Moehring RW, Staheli R, Miller BA, Chen LF, Sexton DJ, Anderson DJ. Central Line-Associated Infec-

tions as Defined by the Centers for Medicare and Medicaid Services’ Hospital-Acquired Condition ver-

sus Standard Infection Control Surveillance Why Hospital Compare Seems Conflicted. Infection

Control & Hospital Epidemiology. 2013; 34(3):238–244.

39. Rivard PE, Rosen AK, Carroll JS. Enhancing patient safety through organizational learning: Are patient

safety indicators a step in the right direction? Health services research. 2006; 41(4p2):1633–1653.

40. Goldman DP, Vaiana M, Romley JA. The emerging importance of patient amenities in hospital care.

New England Journal of Medicine. 2010; 363(23):2185–2187.

PMID: 21121830

Private rooms for reducing central line-associated bloodstream infections

PLOS ONE | July 27, 2018 11 / 12



41. Detsky ME, Etchells E. Single-patient rooms for safe patient-centered hospitals. Jama. 2008; 300

(8):954–956. PMID: 18728270

42. Hendrich AL, Fay J, Sorrells AK. Effects of acuity-adaptable rooms on flow of patients and delivery of

care. American Journal of Critical Care. 2004; 13(1):35–45. PMID: 14735646

43. CDC. Healthcare-associated Infections (HAI) Progress Report [Internet]. 2016 [cited 2017 Sep 10].

Available from:

44. Pronovost PJ, Marsteller JA, Goeschel CA. Preventing bloodstream infections: a measurable national

success story in quality improvement. Health Affairs. 2011; 30(4):628–634.

hlthaff.2011.0047 PMID: 21471482

Private rooms for reducing central line-associated bloodstream infections

PLOS ONE | July 27, 2018 12 / 12



Copyright of PLoS ONE is the property of Public Library of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder’s express written permission. However, users may print, download, or email articles for individual use.

"Is this question part of your assignment? We can help"