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1-Mary and John want to have a second child. They have a 10-year-old with Down syndrome, and they have questions about the risks of having a second child with Down syndrome.
Explain the risk for the development of Down syndrome and the recurrence risk in a second pregnancy.
2-Fill in the Punnett squares on this document for cystic fibrosis (both parents are carriers) and Marfan syndrome (one parent is affected and one is unaffected) and discuss the gender distribution, risks of being a carrier, or affected. Discuss risks for subsequent births.